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However, their poor in vivo stabilityand membrane permeability impede the thriving of peptide-based therapeutics.To overcome their instability in vivo, aided by native chemical ligation and mir-ror image phage display, several proteolysis-resistant D-peptide inhibitorstermed D-PMI-?, ?, ? were identied to bind MDM2 with K d values of50–200 nM [79]. The most concerning obstetric outcome is prematurity. Het-erozygous familial hypercholesterolemia is the mostcommon (1/300–1/500) Mendelian trait in humanscausing premature CVD

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The expiratory time constant (?exp) isshown as the slope of the measured expiratory limb of thetidal ?ow–volume curve (solid line). Typical features include ulcerations interspersed with areas ofnormal mucosa, cobblestoning, and rectal sparing.

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