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Rittman and Perren established an early experimental model in sheep to evaluate the impact of fixation sta-bility on healing in an infected fracture. Biofilmbacteria are up to 1000-fold more resistant to antibiotics than planktonic bacteria .This explains the persistence of implant-associated infection once it is established.
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(1998) Epidemiology and genetics ofessential tremor. (1) increases risk of infection and(2) is not necessary.